“I wish I could forget I had explosive diarrhea” (Cyclospora and Transient Global Amnesia)
Today, Asif and Ali cover TWO medical topics. First, Ali asks Asif about the parasite Cyclospora which is causing outbreaks of explosive diarrhea in large parts of the US (4:13). He explains how the parasite spreads through contaminated food and water—most commonly fresh produce rather than person-to-person contact—why it has become an increasing concern with the globalization of the food supply, and why simply washing fruits and vegetables cannot completely eliminate the risk. He then reviews who is most vulnerable to severe illness, how the infection is diagnosed and treated, and examines notable outbreaks linked to foods such as basil and raspberries, as well as the ongoing record-setting outbreak affecting multiple U.S. states. Finally, they discuss practical prevention strategies. EXTRA at 17:13 the guys provide an update on the outbreak, including the links to lettuce served at Taco Bell and supplied by Taylor Farms.
Then since veteran journalist Katie Couric publicly described her recent episode of transient global amnesia (TGA) (20:56), Ali asks Asif about the science behind one of neurology's most dramatic—but usually benign—memory disorders. He discusses what TGA is, why people suddenly lose the ability to form new memories while remaining awake and aware of who they are, and why they repeatedly ask the same questions during an episode. He then reviews the typical symptoms, who is most commonly affected, possible triggers such as physical exertion and emotional stress, the proposed role of the hippocampus and migraine, and how TGA is diagnosed. Asif then explains how physicians distinguish TGA from stroke and other neurological emergencies, why brain imaging is often performed, the expected recovery, and the risk of recurrence.
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Show Notes:
- Cyclospora Cayetanensis—Major Outbreaks from Ready to Eat Fresh Fruits and Vegetables: https://pmc.ncbi.nlm.nih.gov/articles/PMC7699734/
- As cyclospora illnesses in U.S. surge to new record, Michigan officials eye lettuce as possible cause: https://www.cbc.ca/news/world/cyclospora-illness-diarrhea-us-michigan-lettuce-9.7270134
- Katie Couric Throwbacks: https://people.com/tv/katie-couric-throwbacks/
- https://www.cnn.com/2020/04/28/entertainment/katie-couric-morning-show-trnd
- Katie Couric, 69, Says ‘Several Hours’ Will ‘Always Be Missing’ After Amnesia Episode: https://www.aarp.org/health/conditions-treatments/katie-couric-amnesia-scare/
- Transient Global Amnesia: https://www.ncbi.nlm.nih.gov/books/NBK442001/
- Taylor Farms lettuce remains the focus of cyclosporiasis investigation, despite false positive test: ://www.cnn.com/2026/07/20/health/taylor-farms-lettuce-cyclospora-investigation
- U.S. health authorities say lettuce served at Taco Bell locations is source of diarrhea-causing outbreak: https://www.cbc.ca/news/world/us-cdc-cyclosporiasis-outbreak-9.7273740
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